I've posted this before in places, but I saw it again mentioned in Smithsonian Magazine, so thought it was time to bring it out again - the weird medical history of the US presidents! Anything you want to know is here and it is really easy to search it. It looks like they are updating it, too, so watch for more great information!
I was checking out Jefferson and I found this:
It has been postulated that Jefferson had Asperger Syndrome, a type of autism compatible with high achievement 4. Dr. Zebra has not evaluated this hypothesis, but his first impulse is that distinguishing disease from eccentricity is very difficult 200 years out.
I loved this because I tell people this all the time - we are guessing on medical information because we are reverse diagnosing! It is almost impossible to be certain on anything and given we treat things differently today, even their recorded symptoms don't really help us!